Half-Life is a first-person shooter that requires the player to perform combat tasks and puzzle solving to advance through the game. Unlike most of its peers at the time, Half-Life used scripted sequences, such as a Vortigaunt ramming down a door, to advance major plot points. Compared to most first-person shooters of the time, which relied on cut-scene intermissions to detail their plotlines, Half-Life's story is told entirely by means of scripted sequences, keeping the player in control of the first-person viewpoint. In line with this, the game has no cut-scenes, and the player rarely loses the ability to control Gordon, who never speaks and is never actually seen in the game; the player sees "through his eyes" for the entire length of the game. Half-Life has no "levels"; it instead divides the game into chapters, whose titles flash on the screen as the player moves through the game. Progress through the world is continuous, except for short pauses for loading.

For the most part the player battles through the game alone, but is occasionally assisted by non-player characters; specifically security guards and scientists who help the player, the former who will fight alongside and both who can assist in reaching new areas and impart relevant plot information. A wide array of enemies populates the game including parasites of Xen such as headcrabs, bullsquids, headcrab zombies, and Vortigaunts. The player also faces human opponents, in particular, Hazardous Environment Combat Unit (HECU) Marines and black ops assassins who are dispatched to contain the extra-dimensional threats and silence all witnesses.